9.5. Ankylosing Spondylitis Disease Activity Score (ASDAS)

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Four numerical rating scales rated 0-10 and a measure of inflammation (either C-reactive protein, CRP, or erythrocyte sedimentation rate, ESR).

Each question is weighted:

ASDAS-CRP =
              0.12 × back pain +
              0.06 × duration of morning stiffness +
              0.11 × patient global +
              0.07 × peripheral pain/swelling +
              0.58 × ln(CRP + 1)

  ... where CRP is measured in mg/L

ASDAS-ESR =
              0.08 x back pain +
              0.07 x duration of morning stiffness +
              0.11 x patient global +
              0.09 x peripheral pain/swelling +
              0.29 x √(ESR)

  ... where ESR is measured in mm/h

9.5.1. Intellectual property rights

TO BE ESTABLISHED. Original paper (Lukas et al. 2009) is copyright 2009 BMJ Publishing Group and European League Against Rheumatism, but status of task itself less clear.

Braun et al. (2014, p. S-100) state “Another major difference between BASDAI and ASDAS is that the latter is entirely in the public domain…”; the last author (van der Heijde) is also the last author of the original article.

9.5.2. History

  • Lukas C, Landewé R, Sieper J, Dougados M, Davis J, Braun J, van der Linden S, van der Heijde D (2009). Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis. Ann Rheum Dis. 68: 18-24. https://www.ncbi.nlm.nih.gov/pubmed/18625618

For copyright status, see also:

  • Braun J, Kiltz U, Baraliakos X, van der Heijde D (2014). Optimisation of rheumatology assessments - the actual situation in axial spondyloarthritis including ankylosing spondylitis. Clin Exp Rheumatol. 32(5 Suppl 85): S96-S104. https://www.ncbi.nlm.nih.gov/pubmed/25365096